Having made three changes, the Whites boss saw his team miss several good opportunities in a dominant first half, with Terriers keeper Alex Smithies making some good saves to keep them out as well.
But they paid the price for those missed chances 19 minutes from time when in-form Town midfielder Oliver Norwood arrowed home a stunning winner.
Freedman felt it illustrated his team's profligacy in front of goal can prove costly as the Whites slipped down to 18th in the Championship table.
Freedman said: “You have to take your opportunities when they come along at this level and we didn’t do that.
“We had three good chances in the first half, didn’t take them and that sets the tone of the game.
“They hit a wonderful strike to win the game into the top corner with what was one of just a few chances for them “It’s a shame because we had dragged ourselves into a decent position to have a push but the last two results have delayed that.
“We didn’t play great but had chances and the difference was that we didn’t take them.
“The good thing is we have another home game on Saturday.
“We will freshen it up a bit and I’m looking for a good reaction.”
Club captain Zat Knight, recalled to the back line tonight, agreed with his manager and called for a massive reaction against Doncaster at the Reebok on Saturday.
Knight said: “It was good to be out there on a personal level but I’m disappointed with the result.
“I think they worked a little bit harder than us and it paid off.
“We didn’t feel that troubled as a defence and then a great strike beats us.
“We had good chances and didn’t take them.
2I felt we have deserved something in both games but need to take these chances that come our way.
“We need a massive performance now on Saturday against Doncaster.”