Medals, trophies and other keepsakes bought at auction last month will be unveiled at Bolton Museum in a display at its Bolton Lives gallery.
It includes his 1958 FA Cup Winners medal and match ball and the England Cap from the 1952 Austria game when he was nicknamed the Lion of Vienna.
The items were sold by the late player's son and daughter.
Bolton Council acquired the collection for £75,427 with the help of a consortium made up of the Friends of Bolton Museum and Art Gallery, National Car Parks (NCP) and Bolton at Home.
Bolton Wanderers joined the consortium after the auction.
Lofthouse, who died two years ago aged 85, played more than 500 games for Bolton and won 33 England caps. tue of Lofthouse was unveiled outside the Reebok Stadium in Bolton.
He scored a total of 255 league goals as well as 30 goals for England.
Bolton Council's cabinet member for culture, councillor Anthony Connell, said: "We were fortunate to be able to secure some of the collection at auction and appreciated the support shown by members of the consortium.
"Nat was clearly a popular sportsman on and off the pitch, demonstrated by the thousands of visitors we had to a commemorative exhibition soon after his death in 2011."
He added: "These 19 items are a snapshot of his success and I hope fans from far and wide will come to the museum once again to see his achievements. They are in his hometown, where they belong, and for the pleasure of the public."
In August, a 9ft (2.7m) bronze statue of Lofthouse was unveiled outside the Reebok Stadium in Bolton.